Energy metabolism disorders and potential therapeutic drugs in heart failure
نویسندگان
چکیده
منابع مشابه
Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure
Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were ran...
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Myocytes of the failing heart undergo impressive metabolic remodelling. The time line for changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the creatine kinase (CK) reaction falls as both creatine concentration ([Cr]) and CK activity fall; increases in [ADP] and [AMP] lead to increases in glucose uptake and utilization; fatty acid oxidation either remains the...
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Energy metabolism is at the crossroad of cell function and dysfunction. Cardiac and skeletal muscle cells, the energy metabolism of which is high, fluctuating, and adaptable to the special needs of the body, have developed sophisticated strategies for synthesizing, transferring, and utilizing energy in accordance with the needs of the body. Adaptation to endurance training mainly involves energ...
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Metabolismo do ferro na insuficiência cardíaca: mecanismos e abordagens terapêuticas Anemia is frequent in heart failure (HF) patients, and is considered an independent factor for worse prognosis. However, it is not known whether anemia causes worsening of the disease course or is only a sign of the patient's cardiac and systemic impairment. The definition of anemia according to the World Healt...
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DESPITE REMARKABLE improvements in cardiac mortality rates during the past decades (4), poor quality of life remains a major concern for patients with heart failure. One of the determinants of quality of life is exercise tolerance (6). Limited exercise capacity can result from multiple abnormalities in heart failure, which include changes in intramuscular metabolism (20, 21, 28, 46), local infl...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2021
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2020.10.007